Journal of nephrology
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Journal of nephrology · Jul 2008
Comparative StudyEffective treatment administration of cyclophosphamide in membranous nephropathy.
Idiopathic membranous nephropathy (IMN) is the most common cause of nephrotic syndrome in adults. In this prospective study, we investigated the efficacy of combined use of oral or pulse cyclophosphamide (CYC) with low-dose steroid on our group of adult IMN patients whose renal function was normal at the time of diagnosis. ⋯ With regard to patients with IMN, the combination of CYC with corticosteroids was beneficial in conserving renal function and in induction of remission of nephrotic syndrome. We observed that pulse CYC treatment significantly increased serum albumin levels when compared with oral CYC.