Journal of nephrology
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Journal of nephrology · Sep 2012
Role of erythropoietin in prevention of amikacin-induced nephropathy.
Aminoglycoside antibiotics are widely used potent bactericidal drugs. However, nephrotoxicity side effects via oxidant injury limit their effectiveness. Erythropoietin (Epo) has been shown to exert pleiotropic effects besides promoting erythrocyte differentiation such as antiapoptotic, antioxidant functions in ischemic and toxic acute renal injury. Therefore we aimed to explore whether Epo is renoprotective in an amikacin-induced nephropathy model in rats. ⋯ As far as we know, the present results are the first to demonstrate a protective effect of exogenous Epo against experimental amikacin-induced renal injury. According to these results, Epo may improve the therapeutic potential of amikacin. More studies are needed for a final conclusion.
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We hypothesized that post-operative serum uric acid (SUA) may be associated with acute kidney injury (AKI). ⋯ We conclude that post-operative SUA is associated with an increased risk for AKI and compares well to conventional markers of AKI.
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Journal of nephrology · May 2012
Randomized Controlled Trial Multicenter StudyA prospective, multicenter, randomized, controlled study: the correction of metabolic acidosis with use of bicarbonate in Chronic Renal Insufficiency (UBI) Study.
A Cochrane Collaboration review (Roderick, Cochrane Data base of systemic reviews 2007, DOI 10.1002/14651858.CD0018.90.pub3) reported that there was no evidence for correction of acidosis by sodium bicarbonate in pre-end-stage renal disease (ESRD) patients, and concluded that randomized controlled trials (RCTs) are necessary to evaluate the benefits and harms of correcting metabolic acidosis in pre-ESRD patients. We wanted to evaluate if the administration of alcaly (mainly sodium bicarbonate) is able to significantly modify renal death and to reduce mortality due to cardiovascular events. ⋯ In conclusion, the Work Group on Conservative Therapy for Chronic Renal Insufficiency proposes this prospective, multicenter, cohort, randomized, controlled study to evaluate the effects of correction of acidosis on the progression of the kidney disease evaluated as renal death in ESRD patients.
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Journal of nephrology · May 2012
High-sensitivity C-reactive protein predicts contrast-induced nephropathy after primary percutaneous coronary intervention.
Few studies have investigated hs-CRP as a risk factor for contrast-induced nephropathy (CIN). The aim of this study was to evaluate the predictive value of high-sensitivity C-reactive protein (hs-CRP) for risk of CIN in patients with acute ST-segment elevation myocardial infarction (STEMI) who were undergoing primary percutaneous coronary intervention (PCI). ⋯ An hs-CRP >16.10 was a significant and independent predictor of CIN after primary PCI in patients with STEMI.
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Journal of nephrology · May 2012
Body mass index has no effect on rate of progression of chronic kidney disease in subjects with type 2 diabetes mellitus.
The incidences of obesity and chronic kidney disease (CKD) are reaching epidemic levels. Recently obesity has been associated with the development of CKD. However, it is unclear whether obesity is a risk factor for the progression of CKD. This study investigated the effect of raised body mass index (BMI, calculated as kg/m2) on the rate of CKD progression in a group of patients with CKD and type 2 diabetes mellitus. ⋯ Raised BMI did not influence the rate of progression of chronic kidney disease in patients with type 2 diabetes mellitus.