Journal of the American Society of Nephrology : JASN
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J. Am. Soc. Nephrol. · May 1995
Review Case ReportsCatastrophic secondary antiphospholipid syndrome with concomitant antithrombin III deficiency.
The association between thrombotic events and primary or secondary antiphospholipid/anticardiolipin syndrome is now well recognized. A spectrum of renal involvement ranging from glomerular thrombosis to renal infarction has been described. ⋯ The patient had an acquired antithrombin III deficiency, and the combination of secondary antiphospholipid syndrome with accompanying antithrombin III deficiency predisposed to thrombosis. Several mechanisms by which antiphospholipid/anticardiolipin antibodies cause thrombosis have been proposed and are briefly reviewed.