Journal of the American Society of Nephrology : JASN
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J. Am. Soc. Nephrol. · Mar 2005
Review Comparative StudyAre 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors renoprotective?
Statins reduce serum cholesterol and cardiovascular morbidity and mortality. The mechanisms for these beneficial effects are reviewed. ⋯ This review critically considers the available data whereby dyslipidemia mediates renal dysfunction by modulating the inflammatory response to diverse cytokines. Also reviewed is the emerging database indicating that statins may modulate renal function by altering the response of the kidney to dyslipidemia.