The Journal of steroid biochemistry and molecular biology
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J. Steroid Biochem. Mol. Biol. · Sep 2015
ReviewMechanisms of drug resistance that target the androgen axis in castration resistant prostate cancer (CRPC).
Castrate resistant prostate cancer (CRPC) is the fatal-form of prostate cancer and remains androgen dependent. The reactivation of the androgen axis occurs due to adaptive intratumoral androgen biosynthesis which can be driven by adrenal androgens and/or by changes in the androgen receptor (AR) including AR gene amplification. ⋯ Clinical experience indicates that with either agent an initial response is followed by drug resistance and the patient clinically progresses on these agents. This article reviews the mechanisms of intrinsic and acquired drug resistance that target the androgen axis and how this might be surmounted.