Annals of epidemiology
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Annals of epidemiology · Mar 2016
Genetically predicted 17beta-estradiol and cardiovascular risk factors in women: a Mendelian randomization analysis using young women in Hong Kong and older women in the Guangzhou Biobank Cohort Study.
The role of estrogen in cardiovascular health remains contested with discrepancies between findings from randomized controlled trials and observational studies. Mendelian randomization, which assesses the effect of lifelong endogenous exposure, may help elucidate these discrepancies. ⋯ Lifetime exposure to estrogen does not appear to be cardioprotective via the cardiovascular disease-related risk factors examined.