Molecular and cellular neurosciences
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Mol. Cell. Neurosci. · Dec 2017
CHI3L1 and CHI3L2 overexpression in motor cortex and spinal cord of sALS patients.
Amyotrophic Lateral Sclerosis (ALS) is a rapidly progressive neurodegenerative disease characterized by the degeneration and death of upper (UMN) and lower (LMN) motor neurons. In the last decade, it has been shown that Chitinases are an important prognostic indicator of neuro-inflammatory damage induced by microglia and astrocytes. ⋯ This study suggests that CHI3L1 and CHI3L2 are associated with the progression of neurodegeneration in motor cortex and spinal cord of sALS patients.