Acta obstetricia et gynecologica Scandinavica
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Acta Obstet Gynecol Scand · Jan 1982
Effect of prostaglandin E2 and F2alpha on the systemic and pulmonary circulation in pregnant anesthetized women.
The hemodynamic effect of prostaglandin F2 alpha (PGF2 alpha) and of prostaglandin E2 (PGE2) was studied in 12 healthy volunteers admitted for suction abortion at 10--12 weeks of gestation. They were anesthesized using natrium thiomebumal, pethidine and pancuronium bromide. PGF 2 alpha was given as an intravenous infusion of 100 micrograms/min, the dose being increased by 100 micrograms every 10 min to a maximum of 300 micrograms/min. ⋯ These changes were followed by an increase in PaO2. PGF2 alpha seems to have a positive inotropic effect on the heart, whereas its response to PGE2 seems to be a result of the peripheral vasodilatation. The slight decrease in systemic blood pressure without change in pulmonary hemodynamics makes PGE2 suitable for induction in patients with cardiopulmonary diseases.
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Acta Obstet Gynecol Scand · Jan 1982
Pain relief during delivery. An evaluation of conventional methods.
The study evaluates the effect of conventional obstetric analgesia on 544 parturients and their newborn infants. The parturients' pain situation was evaluated with respect to both the effect of pain relief given, and the total pain experience in the first and second stage. This gave a more correct view of the parturients' pain situation and effectiveness of the analgesic procedures that if one or the other estimation was used separately. ⋯ Severe to almost unbearable pain was experienced by about 60% of all parturients in the first stage as well as in the second stage. The duration of labor showed a strong positive correlation (p less than 0.0001) to the pain intensity in the first stage and a strong negative correlation (p less than 0.0001) to the degree of cervical dilation at admission. No adverse effects on the newborn infants were seen, apart from the well-known association between the drug--delivery interval and the slightly depressant effects of pethidine.