Acta obstetricia et gynecologica Scandinavica
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Acta Obstet Gynecol Scand · Jan 1983
Randomized Controlled Trial Comparative Study Clinical TrialOral oxytocics for induction of labor. A randomized study of prostaglandin E2 tablets and demoxytocin resoriblets.
A randomized comparative study of 387 consecutive patients admitted for induction of labor was carried out using two orally administered oxytocics (prostaglandin E2 tablets (Prostin) or Demoxytocin resoriblets for buccal administration (Sandopart)), the results of which are reported here. One-hundred and twenty-three cases were suitable for primary amniotomy; of these 48 were given PGE2 tablets and 75 received demoxytocin resoriblets. In a further 264 cases, primary amniotomy was inadvisable and of these, 133 patients were allotted to the PGE2 treatment group and 131 to treatment with demoxytocin. ⋯ However, a higher incidence of vomiting and diarrhea were observed in patients treated with PGE2 tablets (11%) as compared with those receiving demoxytocin (1.5%). There was no difference with regard to the induction-delivery time, nor to the different stages of labor between otherwise comparable treatment groups when the induction was successful. It is concluded in respect of induction of labor using orally administered oxytocics that PGE2 (tablets) are preferable to demoxytocin (resoriblets) as it is the more effective of the two.
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Acta Obstet Gynecol Scand · Jan 1983
Comparative StudyMeasurement of cardiac stroke volume by impedance cardiography in the last trimester of pregnancy.
Simultaneous determination of cardiac stroke volume by impedance cardiography and the dye dilution technique was compared in 10 women during the last trimester of pregnancy. Measurements were performed in different body positions to investigate the influence of body position on stroke volume. The correlation coefficient for all measurements was 0.87. ⋯ These changes in stroke volume according to body position were equally evident by both methods. Impedance cardiography is a safe, reliable, non-invasive technique for the measurement of changes in stroke volume during late pregnancy. The ability of impedance cardiography to determine changes in stroke volume was unaffected by changes in body position.
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Acta Obstet Gynecol Scand · Jan 1983
Variations in the effect of epidural morphine in gynecological and obstetric patients.
A prospective study was performed on the effect of epidural morphine (2 mg in 10 ml of saline) in three groups of patients: (1) following gynecological operations, 60; (2) following cesarean section, 120; (3) patients in active labor, 30. Pain relief in the first group was uniformly and almost invariably complete for up to 24 hours. In the second group spasmodic visceral pain was felt after about 10 hours, relieved by light analgesics. ⋯ Neither motor nor sympathetic block were noted. The somatic effect of epidural morphine was reliable and uniform, whereas visceral pain was poorly affected. The side effects cause relatively little disturbance at the dose used.
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Acta Obstet Gynecol Scand · Jan 1983
Comparative StudyGastrin and gastrointestinal dyspepsia in pregnancy.
Fasting serum gastrin (SG) concentration and the SG response to a standard protein meal were investigated in 8 women with upper gastrointestinal dyspepsia in the 36th week of pregnancy and again 8 weeks after parturition, when the dyspepsia had disappeared. The fasting SG concentration was significantly higher (p less than 0.05) during pregnancy than post partum, whereas no statistically significant difference was found between the SG response to a protein meal stimulation during pregnancy vs. post partum. The demonstrated variations in gastrin secretion during and after pregnancy offer no explanation for the upper gastrointestinal dyspepsia of our patients.
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Acta Obstet Gynecol Scand · Jan 1982
Pain relief during delivery. An evaluation of conventional methods.
The study evaluates the effect of conventional obstetric analgesia on 544 parturients and their newborn infants. The parturients' pain situation was evaluated with respect to both the effect of pain relief given, and the total pain experience in the first and second stage. This gave a more correct view of the parturients' pain situation and effectiveness of the analgesic procedures that if one or the other estimation was used separately. ⋯ Severe to almost unbearable pain was experienced by about 60% of all parturients in the first stage as well as in the second stage. The duration of labor showed a strong positive correlation (p less than 0.0001) to the pain intensity in the first stage and a strong negative correlation (p less than 0.0001) to the degree of cervical dilation at admission. No adverse effects on the newborn infants were seen, apart from the well-known association between the drug--delivery interval and the slightly depressant effects of pethidine.