European cytokine network
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European cytokine network · Oct 2012
Relationship between a pro- and anti-inflammatory cytokine imbalance and depression in haemodialysis patients.
Depression represents the most frequent psychiatric disorder in patients on maintenance haemodialysis (HD), and it might be associated with secretion of inflammatory cytokines. In this study, we explore the possible correlations between depression and pro-inflammatory (IL-1β, IL-6, and TNF-α), anti-inflammatory (IL-10) cytokines, as well as high-sensitivity C-reactive protein (hs-CRP) serum levels. ⋯ Maintenance HD patients with symptoms of depression may have higher serum levels of IL-6, a IL-6-to-IL-10 ratio, and lower haemoglobin concentrations. An imbalance between pro- and anti-inflammatory cytokines may play an important role in the pathogenesis of depression in HD patients.