Neuroreport
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Although it has been shown that sevoflurane exposure could impair the cognitive function, there are few effective treatments to prevent this disorder. Suberoylanilide hydroxamic acid (SAHA), an inhibitor of histone deacetylase, plays an important role in hippocampal memory formation, which has been proven to enhance memory. As such, we explored whether SAHA could improve the memory impairment induced by sevoflurane in adult mice. ⋯ SAHA also significantly reversed the decreases in Ac-H3, brain-derived neurotrophic factor, tropomyosin-related kinase B, and p-cAMP response element-binding expressions induced by sevoflurane exposure, and reduced the level of apoptosis-related protein cleaved caspase-3. We concluded that cognitive and synaptic plasticity impairments induced by sevoflurane exposure could be reversed by normalizing the histone acetylation state. The effect is related to inhibiting cell apoptosis and activating the brain-derived neurotrophic factor/tropomyosin-related kinase B/cAMP response element-binding signaling pathway in the hippocampus.