Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
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Blood Coagul. Fibrinolysis · Mar 2009
Review Meta AnalysisAre batroxobin agents effective for perioperative hemorrhage in thoracic surgery? A systematic review of randomized controlled trials.
The objective of the present study was to evaluate the effect of batroxobin agents on perioperative hemorrhage in thoracic surgery. We systematically searched Cochrane Library, Pubmed, EMBASE and the China Biological Medicine CD-ROM Databases up to August 2007. Reference lists of all included studies and of reviews related to the topic of the present systematic review were manually searched. ⋯ Mean differences at different time points after operation ranged from -15 ml (95% CI, -31.77 to 1.77) to -150.60 ml (95% CI, -179.26 to -121.94). Although most of the differences between the batroxobin agents group and the no treatment group were statistically significant, clinical value was limited. There is not enough evidence supporting any benefit of batroxobin agents for hemorrhage during thoracic surgery.