The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
-
J. Heart Lung Transplant. · Jul 2010
Case ReportsMinimally invasive, off-pump explant of a continuous-flow left ventricular assist device.
The left ventricular assist device (LVAD) has been used successfully for bridge to transplant and destination therapy. In some cases, myocardial recovery is possible and allows LVAD explantation. We describe a novel explant technique for the HeartMate II LVAD using small incisions on a beating heart, without cardiopulmonary bypass.
-
J. Heart Lung Transplant. · Jul 2010
Increased net gelatinase but not serine protease activity in bronchiolitis obliterans syndrome.
Bronchiolitis obliterans syndrome (BOS) is the main long-term complication after lung transplantation. Previous studies indicate that neutrophil mobilization causes high protease concentrations in the lung allograft during BOS. This study assessed net protease activity and the functional aspect of proteases in BOS. ⋯ Our study supports that there is an unopposed increase in gelatinase activity in BOS, which in part is likely to be accounted for by MMP-9 from local neutrophils. No corresponding evidence was found for serine protease activity.
-
J. Heart Lung Transplant. · Jul 2010
Comparative StudyCardiac reanimation for donor heart transplantation after cardiocirculatory death.
This study was conducted in donor hearts obtained after cardiocirculatory death (DCD) to determine whether pre-reperfusion cardioplegia, followed by warm blood perfusion, is superior to cold storage in preserving function sufficient for transplantation. ⋯ For DCD hearts, a strategy of pre-reperfusion cardioplegia, followed by continuous warm blood perfusion, is superior to cold storage. These results suggest DCD hearts may be more suitable for transplantation after continuous warm blood perfusion than after cold storage.