Journal of neuroimaging : official journal of the American Society of Neuroimaging
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Aquaporin 4 (AQP-4) is the most abundant aquaporin isoform in the brain. Alterations in its expression and distribution have been correlated with the progression of several clinical disorders; however, the specific roles of AQP-4 in those disorders are not well understood. Visualizing AQP-4 in vivo is expected to provide fresh insights into its roles in disease pathology, as well as aiding the clinical assessment of those disorders. ⋯ Based on these initial results, we believe [11C]TGN-020 PET will be valuable in determining the role of AQP-4 in disease progression, and for the clinical assessment of water homeostasis under various settings.
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As magnetic resonance-guided focused ultrasound (MRgFUS) sonothrombolysis relies on mechanical rather than thermal mechanisms to achieve clot lysis, thermometry is not useful for the intraoperative monitoring of clot breakdown by MRgFUS. Therefore, the purpose of this study was to evaluate the optimum imaging sequence for sonothrombolysis. ⋯ T2 is the most appropriate sequence for the evaluation of mechanical MRgFUS sonothrombolysis of an in vitro clot. These findings are consistent across the oxidative states of clot up to 48 hours.
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To report a novel endovascular coiling technique for ligation of aneurysms presenting with cranial neuropathy. ⋯ This technique may be considered in patients presenting with compressive cranial neuropathy and an aneurysm configuration that allows selective coiling of the inflow zone.
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Isolated focal common carotid artery dissection is a rare condition. ⋯ Focal isolated common carotid artery dissection is a rare condition not to be overlooked. This case presents an incidental finding possibly of traumatic nature. In the presence of concomitant migraine its causal embolic relation to the transient word-finding difficulties must remain open.
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The pathological process of Huntington's disease (HD) preferentially targets spiny neurons in the striatum, with later involvement of the substantia nigra and other structures. The purpose of this study is to investigate the nigrostriatal dopaminergic system in a genetically confirmed HD family. ⋯ We showed that the postsynaptic part of the nigrostriatal pathway was involved. The presynaptic part is usually not affected but could occur in very advanced cases. Our findings suggest that SPECT imaging of D2 receptors is useful for diagnosing and monitoring HD.