Acta psychiatrica Scandinavica
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Acta Psychiatr Scand · Feb 2015
Review Meta AnalysisThe prevalence of pain in bipolar disorder: a systematic review and large-scale meta-analysis.
To conduct a meta-analysis investigating the prevalence of pain in people with bipolar disorder (BD). ⋯ People with BD experience significantly increased levels of pain (particularly chronic pain and migraine). The assessment and treatment of pain should form an integral part of the management of BD.
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Acta Psychiatr Scand · Feb 2015
Clinical TrialCorrelation of plasma brain-derived neurotrophic factor and metabolic profiles in drug-naïve patients with bipolar II disorder after a twelve-week pharmacological intervention.
Brain-derived neurotrophic factor (BDNF) is thought to be involved in the pathophysiology of bipolar disorder (BD) and metabolic syndrome. We investigated the correlation between plasma BDNF with mood symptoms and metabolic indices in patients with BD-II over a 12-week pharmacological intervention. ⋯ We found initial evidence of a positive correlation between plasma BDNF levels and BMI, low-density lipoprotein and total cholesterol in drug-naïve patients with BD-II. The specific function of BDNF in regulating and maintaining peripheral metabolic health requires additional investigation.