European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
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Carcinoma of the colon is usually associated with conditions such as familial adenomatous polyposis, and ulcerative colitis. Primary carcinoma of the colon is very rare in children. ⋯ All children had poorly differentiated, highly aggressive tumours. In spite of surgery and adjuvant treatment, the survival was dismal with all the children dying within one year of presentation.
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Hyperlactaemia has been shown to predict mortality in preterm babies undergoing intensive care. The value of such measurement has not been evaluated in babies undergoing laparotomy for necrotising enterocolitis (NEC). The aim of this study was to determine whether peri-operative blood lactate measurements (L) can be used to predict outcome in preterm babies with necrotising enterocolitis. ⋯ This study suggests that elevation of L in the pre-operative period carries a poor prognosis in babies with NEC. As L was not significantly different between babies who had necrotic bowel and those who had a healthy bowel, we postulate that it reflects inadequate global tissue oxygen delivery rather than local disease process. Pre-operative optimisation of oxygen delivery has been shown to reduce mortality in high-risk adult surgical patients. Babies with NEC may also benefit from further peri-operative resuscitation.