The Journal of veterinary medical science
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After peripheral nerve injury, Wallerian degeneration (WD) occurs in the distal nerve segment. During the process of degeneration, Schwann cells (SCs) dedifferentiate, proliferate and migrate to align in "bands of Büngner", providing structural guidance and growth-promoting substrates to regenerating axons. The molecular signals that trigger SCs migration remain unclear. ⋯ Combined inhibition of ERK1/2 and AKT activity resulted in a significant decrease in SCs motility. These molecular characteristics suggest that both the ERK1/2 and AKT signals are involved in the migratory potential of SCs. It may be helpful to understand the process of nerve regeneration and perspective on promoting peripheral nerve regeneration.
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The purpose of this study was to quantitatively assess the pupillary light reflex (PLR) in normal and anesthetized dogs using a pupillometer. Eleven dogs (20 eyes) of various breeds were included. PLRs were measured with a handheld pupillometer in dim light before and during anesthesia. ⋯ NPi,%CH, CV and MCV were significantly decreased during anesthesia compared with the pre-anesthesia data. The results suggest that atropine-xylazine-ketamine combination anesthesia depresses the PLR. Additionally, this study demonstrates the feasibility of the use of a pupillometer in dogs.