Journal of magnetic resonance imaging : JMRI
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J Magn Reson Imaging · Mar 2007
Randomized Controlled Trial Comparative StudyDose comparison of single- vs. double-dose in contrast-enhanced magnetic resonance angiography of the carotid arteries: Intraindividual cross-over blinded trial using Gd-DTPA.
To compare the intraindividual differences of single-dose (D(S)) and double-dose (D(D)) gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA)-enhanced magnetic resonance angiography (MRA) in the carotid arterial territory, an open-label single-center trial with blinded evaluations by two independent radiologists was undertaken. ⋯ Our results demonstrate that while a double dosing of contrast agent does increase SNR, it does not lead to further improvement in visual and perceptual image quality. A single dosage of approximately 0.1 mmol/kg body weight (bw) Gd-DTPA may be the preferable dosage in the carotid arteries.