Journal of magnetic resonance imaging : JMRI
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J Magn Reson Imaging · Nov 2013
ReviewDisclosing incidental findings in brain research: the rights of minors in decision-making.
MRI is used routinely in research with children to generate new knowledge about brain development. The detection of unexpected brain abnormalities (incidental findings; IFs) in these studies presents unique challenges. While key issues surrounding incidence and significance, duty of care, and burden of disclosure have been addressed substantially for adults, less empirical data and normative analyses exist for minors who participate in minimal risk research. ⋯ However, we found little discussion about the involvement of minors in decisions about disclosure of IFs in the brain, especially for IFs of low clinical significance. In response, we propose a framework for managing IFs that integrates practical considerations with explicit appreciation of rights along the continuum of maturity. This capacity-adjusted framework emphasizes the importance of involving competent minors and respecting their right to make decisions about disclosure.
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J Magn Reson Imaging · Nov 2013
Comparative StudyClinical application of controlled aliasing in parallel imaging results in a higher acceleration (CAIPIRINHA)-volumetric interpolated breathhold (VIBE) sequence for gadoxetic acid-enhanced liver MR imaging.
To determine whether a controlled aliasing in parallel imaging results in higher acceleration (CAIPIRINHA) technique can improve the image quality of three-dimensional (3D), T1-weighted gradient echo (T1w-GRE) imaging compared with the use of a standard, parallel acquisition technique (PAT). ⋯ The CAIPIRINHA-VIBE was able to provide a higher spatial resolution, T1-weighted imaging with better image quality compared with a standard VIBE.
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J Magn Reson Imaging · Nov 2013
Relationships between hypercarbic reactivity, cerebral blood flow, and arterial circulation times in patients with moyamoya disease.
To evaluate the correlation between angiographic measures of Moyamoya disease and tissue-level impairment from measurements of tissue perfusion and cerebrovascular reactivity (CVR). ⋯ Correlative measures between angiography and hemodynamic methods suggest that BOLD and ASL could be used for expanding the diagnostic imaging infrastructure in Moyamoya patients and potentially tracking tissue response to revascularization.
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J Magn Reson Imaging · Nov 2013
Quantitative tractography and tract shape modeling in amyotrophic lateral sclerosis.
To investigate brain-wide white matter structural changes associated with amyotrophic lateral sclerosis (ALS) using an automatic single seed point tractography-based segmentation method, probabilistic neighborhood tractography (PNT), which provides quantitative measures of both tract integrity and shape. ⋯ ALS, although particularly affecting CST, is associated with subtle changes in white matter tract integrity and shape in several other major fibers within the brain. Correlations between CST integrity and disease progression rate suggest that quantitative tractography may provide useful biomarkers of disease evolution in ALS.
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J Magn Reson Imaging · Nov 2013
Volumetric late gadolinium-enhanced myocardial imaging with retrospective inversion time selection.
To develop and validate a novel free-breathing 3D radial late gadolinium-enhanced magnetic resonance imaging technique (3D LGE-MRI) with isotropic resolution and retrospective inversion time (TI) selection for myocardial viability imaging. ⋯ The 3D LGE-MRI technique demonstrated in this study is a promising alternative for the assessment of myocardial viability in patients who have difficulty sustaining breath-holds for the clinical standard 2D LGE-MRI.