Journal of magnetic resonance imaging : JMRI
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J Magn Reson Imaging · Dec 2013
Randomized Controlled Trial Comparative StudyHyperpolarized (3) He and (129) Xe MRI: differences in asthma before bronchodilation.
To compare hyperpolarized helium-3 ((3) He) and xenon-129 ((129) Xe) MRI in asthmatics before and after salbutamol inhalation. ⋯ In asthma, hyperpolarized (129) Xe MRI may help reveal ventilation abnormalities before bronchodilation that are not observed using hyperpolarized (3) He MRI.
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J Magn Reson Imaging · Dec 2013
Analysis of quantitative magnetic resonance imaging and biomechanical parameters on human discs with different grades of degeneration.
To establish relationships between quantitative MRI (qMRI) and biomechanical parameters in order to help inform and interpret alterations of human intervertebral discs (IVD) with different grades of degeneration. ⋯ Our studies indicate that qMRI can be used as a noninvasive diagnostic tool in the detection of IVD properties with the potential to help interpret and detect early, middle, and late stages of degeneration. QMRI of human IVD can therefore become a very important diagnostic assessment tool in determining the functional state of the disc.
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J Magn Reson Imaging · Dec 2013
Noncontrast-enhanced magnetic resonance angiography and venography imaging with enhanced angiography.
To achieve simultaneous high-resolution magnetic resonance angiography and venography (MRAV) imaging in terms of enhanced time-of-flight (TOF) angiography and susceptibility-weighted imaging (SWI), with a clear separation of arteries and veins. ⋯ Using the proposed interleaved double-echo sequence along with the NLS postprocessing method, one can simultaneously obtain both high-quality SWI and significantly enhanced TOF MRA with clear separation of arterial and venous maps.
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J Magn Reson Imaging · Dec 2013
Multicenter Study Comparative Study Clinical TrialMulticenter measurements of myelin water fraction and geometric mean T2 : intra- and intersite reproducibility.
To assess the reproducibility of myelin water fraction (MWF) and geometric mean T2 (GMT2 ), which are in vivo markers of pathological changes underlying disability and progression in diseases such as multiple sclerosis. ⋯ MWF and GMT2 measures are reproducible between scans and across sites with an equivalent MR scanner and sequence protocol. Multicenter clinical trials using quantitative T2 relaxation are feasible.
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J Magn Reson Imaging · Dec 2013
Controlled Clinical TrialWithin-lesion differences in quantitative MRI parameters predict contrast enhancement in multiple sclerosis.
To investigate the relationship between quantitative magnetic resonance imaging (qMRI) and contrast enhancement in multiple sclerosis (MS) lesions. We compared maps of T1 relaxation time, proton density (PD), and magnetization transfer ratio (MTR) between lesions with and without contrast enhancement as quantified by the amount of T1 shortening postcontrast agent (CA). ⋯ Contrast enhancement in MS quantified by relative T1 shortening may be predicted by precontrast abnormalities of T1, PD, and MTR and likely represents blood-brain barrier damage.