Journal of magnetic resonance imaging : JMRI
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J Magn Reson Imaging · Dec 2015
Comparative StudyComparing tract-based spatial statistics and manual region-of-Interest labeling as diffusion analysis methods to detect white matter abnormalities in infants with hypoxic-Ischemic encephalopathy.
To compare manual region of interest (ROI) labeling and tract-based spatial statistics (TBSS) by their ability to detect group-wise differences in fractional anisotropy (FA) in the neonatal brain. ⋯ Manual ROI labeling and TBSS are comparable methods of diffusion analysis to detect group differences in FA in the neonatal brain.
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J Magn Reson Imaging · Dec 2015
Increased speed and image quality in single-shot fast spin echo imaging via variable refocusing flip angles.
To develop and validate clinically a single-shot fast spin echo (SSFSE) sequence utilizing variable flip angle refocusing pulses to shorten acquisition times via reductions in specific absorption rate (SAR) and improve image quality. ⋯ vrfSSFSE increases speed at 3T over conventional SSFSE via reduced SAR, and when combined with full-Fourier acquisition can improve image quality, although with some increased sensitivity to cardiac motion-related signal loss.
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J Magn Reson Imaging · Dec 2015
Subcortical gray matter segmentation and voxel-based analysis using transverse relaxation and quantitative susceptibility mapping with application to multiple sclerosis.
To investigate subcortical gray matter segmentation using transverse relaxation rate (R2 *) and quantitative susceptibility mapping (QSM) and apply it to voxel-based analysis in multiple sclerosis (MS). ⋯ Automatic segmentation of iron-rich deep gray matter can be improved by incorporating QSM. Voxel-based evaluation yielded increased R2 * and QSM in MS subjects in all four nuclei studied with R2 *, benefiting the most from localized analysis over whole-structure measures.
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J Magn Reson Imaging · Dec 2015
Age-dependency of glycosaminoglycan content in lumbar discs: A 3t gagcEST study.
To analyze age-dependency of glycosaminoglycan content using gagCEST (glycosaminoglycan chemical exchange saturation transfer) imaging in lumbar intervertebral discs of healthy volunteers. ⋯ We show a decreased gagCEST effect likely corresponding to decreasing glycosaminoglycans with aging. Hence, age-matched analysis of gagCEST imaging may be necessary in future studies.
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J Magn Reson Imaging · Dec 2015
Semi-automated hippocampal segmentation in people with cognitive impairment using an age appropriate template for registration.
To evaluate a new semi-automated segmentation method for calculating hippocampal volumes and to compare results with standard software tools in a cohort of people with subjective memory complaints (SMC) and mild cognitive impairment (MCI). ⋯ These results suggest that an age appropriate registration template might be a more accurate alternative to calculate hippocampal volumes when manual segmentation is not feasible.