Annals of hematology
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Annals of hematology · Aug 2010
Human promoter mutations unveil Oct-1 and GATA-1 opposite action on Gfi1b regulation.
Growth factor-independence 1b (Gfi1b) is a zinc finger transcription factor essential for erythroid and megakaryocytic development. To better understand Gfi1b regulation and to know the implication of the level of expression of this gene in human pathology, we have searched for promoter punctual sequence variations in 214 patients with different hematological diseases. We found two previously unknown congenital mutations at evolutionary conserved GATA and octamer-binding (Oct) transcription factor sites. ⋯ Finally, we found that GATA-1 and Oct-1 are the main components of each complex. This study provides evidences of a new mechanism for Gfi1b repression. This is also the first report of Gfi1b mutations with a functional implication; further investigation and follow-up will clarify the involvement of these mutations in hematological disease.
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Annals of hematology · Aug 2010
Letter Case ReportsPneumocystis jiroveci pneumonia detected by FDG-PET.