Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS
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Anasthesiol Intensivmed Notfallmed Schmerzther · Dec 1991
Case Reports[Fulminant malignant hyperthermia during the 6th general anesthesia using volatile anesthetics].
We report on the fulminant crisis of malignant hyperthermia occurring in a 30-year-old female during kidney transplantation. In the past, she had been anaesthetised repeatedly without complications. Anaesthesia was induced with thiopental and vecuronium and continued with isoflurane/N2O/O2. ⋯ A surgical revision required the next day because of bleeding was done under dantrolene cover and took an uncomplicated course. The patient was extubated 7.5 hours after the second intervention and transferred to a normal ward after 4 days. A subsequently performed in vitro contracture test clearly revealed susceptibility to malignant hyperthermia.
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Anasthesiol Intensivmed Notfallmed Schmerzther · Dec 1991
Biography Historical Article[Friedrich Wilhelm Adam Sertürner−the discoverer of morphine].
Friedrich Wilhelm Adam Sertürner (1783-1841) was one of the most outstanding pharmacists who significantly influenced the transformation of pharmaceutical chemistry from a state of alchemistry to an acknowledged branch of science at the end of the 18th century. At the age of twenty-one, Sertürner was the first to report on some results concerning the substance which was thought to be responsible as the "sleeping-agent". ⋯ To have an idea of the effects of the drug, Sertürner was able to confirm the hypnotic as well as the analgesic properties of morphine that were well-known to him since the had performed animal tests. Since he could demonstrate the alkaline qualities of morphine, something absolutely new at that time, Sertürner became the co-founder and promoter of a new type of chemistry now known as alkaloid chemistry.
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Anasthesiol Intensivmed Notfallmed Schmerzther · Dec 1991
Review[An attempt to reconcile differences of opinion in the field of malignant hyperthermia].
Two of the persisting controversies concerning malignant hyperthermia (MH) are discussed: storing and dosage of dantrolene and preoperative tactics to be followed with patients who are MH-susceptible. Reasons are presented for the obligation to store sufficient amounts of dantrolene in every operating suite. The second part discusses the question of pretreatment of MH-susceptible patients with dantrolene.
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Anasthesiol Intensivmed Notfallmed Schmerzther · Dec 1991
Case Reports[The early diagnosis of malignant hyperthermia--the place of end-expiratory CO2 monitoring].
The authors report on the course of a fulminant malignant hyperthermia (MH) associated with laminectomy in a 29-year-old man who had been healthy up to that time. Succinylcholine and isoflurane were considered to be the causative triggering agents. ⋯ Residue-free restitution was achieved within a few days. Decisive for an early detection of MH is the routine performance of end-expiratory CO2 measurement which is definitely superior to temperature control and significantly reduces the time that elapses before treatment is initiated.