Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS
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Anasthesiol Intensivmed Notfallmed Schmerzther · Feb 2001
[Epileptic seizures from etomidate? The human Kv1.1 potassium channel in humans].
It is a matter of dispute whether etomidate exhibits an epileptogenic action. It is also disputed whether frequently observed myocloni induced by etomidate are related to seizure-like activity in the EEG. The clinical effects of anaesthetic agents reflect their molecular action. A possible epileptogenic action of etomidate should, therefore, result from action on a molecular target that has yet to be identified. Suppression of Kv1.1 channels may be associated with epilepsy in men. Inhibition of Kv1.1 channels by etomidate at clinically relevant concentrations would, thus, argue in favour of an epileptogenic action of etomidate. ⋯ The small effect of etomidate on human Kv1.1 channels at these concentrations questions an epileptogenic action of etomidate caused by inhibition of Kv1.1 channels.
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Anasthesiol Intensivmed Notfallmed Schmerzther · Feb 2001
Comment Letter[Comments on "Severity in the prognosis following head-brain trauma." Krier C., Kienzle F. Anäesthesiol Intensivmed Notfallmed Schmerzther 2000;35:63-66 and "Outcome factors in severe head-brain trauma." Thomas A et al. Anästhesiol Intensivmed Notfallmed Schmerzther 2000;35:91-8].