Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS
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Anasthesiol Intensivmed Notfallmed Schmerzther · Dec 1991
Biography Historical Article[Friedrich Wilhelm Adam Sertürner−the discoverer of morphine].
Friedrich Wilhelm Adam Sertürner (1783-1841) was one of the most outstanding pharmacists who significantly influenced the transformation of pharmaceutical chemistry from a state of alchemistry to an acknowledged branch of science at the end of the 18th century. At the age of twenty-one, Sertürner was the first to report on some results concerning the substance which was thought to be responsible as the "sleeping-agent". ⋯ To have an idea of the effects of the drug, Sertürner was able to confirm the hypnotic as well as the analgesic properties of morphine that were well-known to him since the had performed animal tests. Since he could demonstrate the alkaline qualities of morphine, something absolutely new at that time, Sertürner became the co-founder and promoter of a new type of chemistry now known as alkaloid chemistry.
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Anasthesiol Intensivmed Notfallmed Schmerzther · Dec 1991
Review[An attempt to reconcile differences of opinion in the field of malignant hyperthermia].
Two of the persisting controversies concerning malignant hyperthermia (MH) are discussed: storing and dosage of dantrolene and preoperative tactics to be followed with patients who are MH-susceptible. Reasons are presented for the obligation to store sufficient amounts of dantrolene in every operating suite. The second part discusses the question of pretreatment of MH-susceptible patients with dantrolene.