Journal of cardiothoracic and vascular anesthesia
-
J. Cardiothorac. Vasc. Anesth. · Feb 1997
Randomized Controlled Trial Clinical TrialIntraoperative plasmapheresis in cardiac surgery.
To determine the effects of intraoperative plasmapheresis on total transfusion requirements, mediastinal drainage, and coagulation. ⋯ After cardiac surgery, intraoperative plasma-pheresis reduces early postoperative bleeding and decreases the need for homologous transfusions.
-
J. Cardiothorac. Vasc. Anesth. · Feb 1997
Randomized Controlled Trial Clinical Trial Controlled Clinical TrialA placebo-controlled trial verifying the efficacy of milrinone in weaning high-risk patients from cardiopulmonary bypass.
To establish the efficacy of the phosphodiesterase inhibitor milrinone in facilitating weaning from cardiopulmonary bypass of high-risk patients with left ventricular dysfunction and/or pulmonary hypertension. ⋯ This placebo-controlled, double-blind study has conclusively demonstrated the benefits of milrinone in facilitating weaning of high-risk patients from cardiopulmonary bypass.
-
J. Cardiothorac. Vasc. Anesth. · Feb 1997
Randomized Controlled Trial Comparative Study Clinical TrialEffects of desflurane and isoflurane on systemic vascular resistance during hypothermic cardiopulmonary bypass.
The objective of this study was to examine the dose-related effects of desflurane and isoflurane on systemic vascular resistance during hypothermic cardiopulmonary bypass. ⋯ Equi-MAC concentrations of desflurane and isoflurane had similar effects on systemic vascular resistance; 0.5 MAC maintained systemic vascular resistance; 1.0 MAC decreased systemic vascular resistance during hypothermic cardiopulmonary bypass.
-
J. Cardiothorac. Vasc. Anesth. · Feb 1997
Randomized Controlled Trial Clinical TrialModel-driven closed-loop feedback infusion of atracurium and vecuronium during hypothermic cardiopulmonary bypass.
This study was designed to investigate the performance of a computer-controlled infusion of atracurium and vecuronium during cardiac surgery requiring hypothermic cardiopulmonary bypass. ⋯ The computer-controlled infusion can be used for the administration of atracurium and vecuronium during CPB.
-
J. Cardiothorac. Vasc. Anesth. · Feb 1997
Comparative StudyHeparin detection by the activated coagulation time: a comparison of the sensitivity of coagulation tests and heparin assays.
Laboratory and point-of-care coagulation tests are frequently obtained to determine the presence of heparin after surgical procedures. The objective of this study was (1) to compare the sensitivity of the activated coagulation time (ACT), activated partial thromboplastin time (aPTT), protamine titration (Hepcon; HMS Medtronic, Hemotec, Englewood, CO), and thromboelastography (TEG) with heparin anticoagulation and (2) to determine how frequently residual heparin is present in the 24-hour period after heparin neutralization in cardiopulmonary bypass (CPB) patients. ⋯ ACT was less sensitive to residual heparin anticoagulation than aPTT, TEG, and whole blood heparin assay. The whole blood heparin assay (Hepcon) provided sensitive and specific data about the presence of residual heparin. Despite the limitation of ACT in detecting heparin, the investigators found that residual heparin was not common in the period after uncomplicated CPB.