Journal of cardiothoracic and vascular anesthesia
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J. Cardiothorac. Vasc. Anesth. · Dec 2003
Influence of isoflurane on left atrial function in dogs with pacing-induced cardiomyopathy: evaluation with pressure-volume relationships.
The actions of volatile anesthetics on left ventricular (LV) function in normal and failing hearts have been previously evaluated, but the effects of these agents on left atrial (LA) function in the presence of LV dysfunction are unknown. The hypothesis was tested that isoflurane alters LA mechanics evaluated with pressure-volume relations. ⋯ The results indicate that isoflurane depresses LA myocardial contractility, impairs LA-LV coupling, and reduces active LA contribution to LV filling in dogs with pacing-induced cardiomyopathy. The impact of isoflurane on LA function in the presence of LV dysfunction has profound effects on cardiac performance.
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J. Cardiothorac. Vasc. Anesth. · Dec 2003
Dose-related effects of theophylline added to modified Euro-Collins solution used for hypothermic preservation of lung.
To investigate the dose-related effects of theophylline in prevention of ischemia-reperfusion injury of the lung. ⋯ The results of this study showed that 400 mg/L and 1000 mg/L of theophylline added to the modified Euro-Collins solution decreased the intermediate products of lipid peroxidation. Theophylline merits further investigation in ischemia-reperfusion studies as a potentially beneficial agent.