Journal of cardiothoracic and vascular anesthesia
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J. Cardiothorac. Vasc. Anesth. · Feb 2007
Clinical TrialThe role of endogenous kallikrein inhibition in perioperative transfusion and adverse outcome in cardiac surgical patients.
The goal of this study was to explore the relationship among endogenous plasma kallikrein inhibition (KI), perioperative bleeding, and adverse outcomes in cardiac surgery. ⋯ Contrary to expectation, higher endogenous KI levels were associated with more blood product transfusion, longer postoperative mechanical ventilation, and hospital length of stay. These findings raise questions as to the role of KI in postoperative outcomes.
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J. Cardiothorac. Vasc. Anesth. · Feb 2007
Clinical TrialTemperature-related differences in mean expired pump and arterial carbon dioxide in patients undergoing cardiopulmonary bypass.
To investigate the relationship between arterial carbon dioxide (PaCO(2)) and mean expired pump CO(2) during cardiopulmonary bypass (PeCPBCO(2)) in patients undergoing cardiac surgery with CPB during steady state, cooling, and rewarming phases of CPB. ⋯ Monitoring the mean expired CO(2) value from the CPB oxygenator exhaust scavenging port with a capnography monitor provides a continuous and noninvasive data source to aid in sweep flow CPB circuit management during CPB.
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J. Cardiothorac. Vasc. Anesth. · Feb 2007
Comparative Study Clinical TrialCardiac output determination from the arterial pressure wave: clinical testing of a novel algorithm that does not require calibration.
The purpose of this study was to evaluate the accuracy and precision of a novel algorithm that evaluates cardiac output by using arterial pressure waveform characteristics. ⋯ This novel arterial pressure cardiac output algorithm provides cardiac output assessments that agree satisfactorily for clinical purposes with intermittent and continuous thermodilution techniques in postoperative cardiac surgical patients. Further study is required for other patient populations and clinical situations.
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J. Cardiothorac. Vasc. Anesth. · Feb 2007
Clinical TrialInhaled nitric oxide in the preoperative evaluation of pulmonary hypertension in heart transplant candidates.
The goal of this study was to evaluate the efficacy of 100% oxygen and inhaled nitric oxide (iNO) in decreasing pulmonary vascular resistance (PVR) and transpulmonary gradient (TPG) in dilated cardiomyopathy patients being evaluated for orthotopic heart transplantation (OHT); who, despite maximal intravenous (IV) dilator therapy, had persistent moderate-to-severe pulmonary hypertension. ⋯ iNO can further improve right ventricular hemodynamics even after presumed optimization with IV vasodilators and serves as a test of PVR reversibility during the preoperative assessment of OHT candidates.