Journal of cardiothoracic and vascular anesthesia
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J. Cardiothorac. Vasc. Anesth. · Aug 2000
Thermal energy balance as a measure of adequate rewarming from hypothermic cardiopulmonary bypass.
To determine whether the amount of heat (thermal energy) used actively to rewarm patients on cardiopulmonary bypass (CPB) was a better indicator of adequate rewarming from hypothermic CPB than core temperature. ⋯ TEB is a better predictor than corresponding values of core temperature on termination of CPB in predicting the coldest postoperative temperature and time to rewarm to 37 degrees C.
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To evaluate the pharmacokinetics of amrinone and its metabolites in neonates and infants after reconstructive surgery for congenital heart disease. ⋯ Amrinone is eliminated at a slower rate in neonates than in infants. The rate of acetylation of amrinone appears to be similar; the differences in the elimination capacity of amrinone are mainly due to the immature renal function in neonates.
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J. Cardiothorac. Vasc. Anesth. · Aug 2000
Pharmacokinetic model-driven infusion of sufentanil and midazolam during cardiac surgery: assessment of the prospective predictive accuracy and the quality of anesthesia.
To evaluate the prospective predictive accuracy and the quality of anesthesia of pharmacokinetic model-driven infusion of sufentanil and midazolam designed to establish and maintain a plasma level of drug during cardiac surgery. ⋯ Pharmacokinetic model-driven infusion of sufentanil and midazolam using the pharmacokinetic sets of Gepts et al and Maitre et al is a safe and accurate anesthetic technique before CPB in adult patients undergoing cardiac surgery when high sufentanil (1 to 10 ng/mL) and low midazolam (100 ng/mL) predicted plasma concentrations are targeted.
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J. Cardiothorac. Vasc. Anesth. · Aug 2000
The effect of modified ultrafiltration on the amount of circulating endotoxins in children undergoing cardiopulmonary bypass.
To determine whether the use of modified ultrafiltration during pediatric cardiopulmonary bypass (CPB) diminishes the load of circulating endotoxins. ⋯ This study strongly suggests that modified ultrafiltration decreases the amount of circulating endotoxins in children undergoing cardiac surgery.
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J. Cardiothorac. Vasc. Anesth. · Aug 2000
Plasma-soluble E-selectin after cardiopulmonary bypass in children: is it a marker of the postoperative course?
To investigate the relationship and possible role of soluble adhesion molecule E-selectin in the postoperative course in children undergoing cardiopulmonary bypass (CPB). ⋯ These results suggest a relationship between CPB-induced mediators and early and late clinical effects. Although the mechanism for the increase of soluble E-selectin remains to be elucidated, the upregulation of soluble E-selectin indicates neutrophil activation, and its inhibition may represent a target for reducing the inflammatory response associated with CPB.