Current opinion in neurobiology
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Curr. Opin. Neurobiol. · Jun 2014
ReviewInterneuronal GABAA receptors inside and outside of synapses.
About 20% of the total number of neurons in the brain are interneurons (INs) that utilize GABA as their neurotransmitter. The receptors for GABA have been well studied in principal cells, but INs also express GABA receptors, in particular the GABAA type (GABAARs), which may also be activated in an autocrine manner by the transmitter released by the INs themselves. As more and more neurological and psychiatric disorders are being discovered to be linked to malfunction or deficits of INs, this review will cover how INs communicate with each other through the activation of synaptic and extrasynaptic GABAARs. The properties of GABAARs specific to INs may differ significantly from those found on principal cells to open the prospect of developing IN-specific drugs.
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Curr. Opin. Neurobiol. · Jun 2014
ReviewSpatiotemporal specificity in cholinergic control of neocortical function.
Cholinergic actions are critical for normal cortical cognitive functions. The release of acetylcholine (ACh) in neocortex and the impact of this neuromodulator on cortical computations exhibit remarkable spatiotemporal precision, as required for the regulation of behavioral processes underlying attention and learning. ⋯ We also review recent studies suggesting that the modulatory influences of ACh on the properties of cortical neurons can have the necessary temporal dynamic range, emphasizing evidence of powerful interneuron subtype-specific effects. We discuss areas that require further investigation and point to technical advances in molecular and genetic manipulations that promise to make headway in understanding the neural bases of cholinergic modulation of cortical cognitive operations.