Neuromuscular disorders : NMD
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Neuromuscul. Disord. · Nov 2001
Case ReportsValproic acid triggers acute rhabdomyolysis in a patient with carnitine palmitoyltransferase type II deficiency.
A 47-year-old man suffering from a bipolar disorder and intermittent myoglobinuria presented with acute rhabdomyolysis with renal failure after starting therapy with valproic acid. On morphological examination, skeletal muscle revealed increased lipid storage. ⋯ Genetic analysis detected the common Ser113Leu substitution on one allele of the CPT2 gene. We conclude that valproic acid should be avoided in patients with CPT type II deficiency.