Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
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Few studies have examined the relationship between mircroRNAs and moyamoya disease (MMD). We performed a study of the significance of let-7c expression in the serum of MMD patients. ⋯ Increased expression of let-7c in MMD patients may contribute to MMD pathogenesis by targeting RNF213. Thus, let-7c may be a potential biomarker for the diagnosis of MMD.
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J Stroke Cerebrovasc Dis · Aug 2015
Comparisons of Predictive Equations for Resting Energy Expenditure in Patients with Cerebral Infarct during Acute Care.
Estimation of resting energy expenditure (REE) is essential in planning nutrition support. Several equations are used for this estimation in the clinical setting. The purpose of this study was to compare the predictive accuracy of existing equations for REE in patients with cerebral infarct during acute care. ⋯ Based on our results, the Harris-Benedict equation provides the most accurate prediction of REE. In addition, the Cunningham and Wang equations may be useful in long-term care settings involving patients at risk of malnutrition resulting in uneven loss of FFM relative to weight.
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J Stroke Cerebrovasc Dis · Aug 2015
The Effects of Pretreatment versus De Novo Treatment with Selective Serotonin Reuptake Inhibitors on Short-term Outcome after Acute Ischemic Stroke.
Selective serotonin reuptake inhibitors (SSRIs) administered in patients following acute ischemic stroke have shown to improve clinical recovery independently of changes in depression. Animal studies have demonstrated that sustained SSRI treatment is superior to short-term SSRI in evoking neurogenesis but how this benefit translates into humans remains to be answered. We hypothesized that in acute ischemic stroke patients, SSRI treatment started before the event leads to improved short-term outcomes compared to de novo SSRI treatment poststroke. ⋯ Our data suggest that SSRI pretreatment may improve clinical outcomes in the early stages of acute ischemic stroke supporting the hypothesis that prolonged SSRI treatment started prestroke is superior to poststroke SSRI.
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J Stroke Cerebrovasc Dis · Aug 2015
Differences Between Vascular Structural Abnormality and Hypertensive Intracerebral Hemorrhage.
How the clinical characteristics and prognosis of various types of vascular structural abnormality-related intracerebral hemorrhage (ICH) differ from those of hypertensive ICH is poorly understood. This lack of understanding poses a problem for differential diagnosis and prognosis. ⋯ Patients with vascular structural abnormality-related ICH are more likely to experience better clinical outcomes than those with hypertensive ICH. GCS score, age, hematoma volume, and ICH etiology are independent predictors of ICH outcome.
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J Stroke Cerebrovasc Dis · Aug 2015
Predictors of Favorable Outcome of Intracranial Basilar Dissecting Aneurysm.
Management of intracranial basilar dissecting aneurysms has been controversial and challenging, and surgical and conservative treatments usually have a bad prognosis. Our study aimed at evaluating the outcomes of endovascular treatment for these lesions and exploring the predictors of favorable outcome. ⋯ Patients with basilar artery dissecting aneurysms treated with stent-assisted coiling had a more favorable outcome than the conservatively treated patients. Stent placement and initial complete occlusion were the favorable factors in patients with basilar dissecting aneurysm.