European psychiatry : the journal of the Association of European Psychiatrists
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Randomized Controlled Trial
Duloxetine in the treatment of major depressive disorder: a placebo- and paroxetine-controlled trial.
Duloxetine doses of 80 and 120 mg/day were assessed for efficacy and safety in the treatment of major depressive disorder (MDD). ⋯ The efficacy of duloxetine at doses of 80 and 120 mg/day in the treatment of MDD was demonstrated. Tolerability, as measured by TEAEs, and safety were similar to paroxetine 20 mg/day and consistent with previous published data on duloxetine in the treatment of MDD.