European psychiatry : the journal of the Association of European Psychiatrists
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Review Meta Analysis
BDNF Val66Met and clinical response to antipsychotic drugs: A systematic review and meta-analysis.
The polymorphic brain-derived neurotrophic factor (BDNF) gene has been postulated to be involved in inter-individual variability response to antipsychotic drugs. ⋯ The present meta-analysis excludes a clinically relevant effect of BDNF Val66Met on antipsychotic drug response per se. Nevertheless, further investigation is still needed to clarify in well-designed, large sample-based studies, the impact of BDNF haplotypes containing the Val66Met polymorphism.