International journal of antimicrobial agents
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Int. J. Antimicrob. Agents · Aug 2018
Multicenter Study Observational StudyPopulation pharmacokinetics of vancomycin in critically ill patients receiving prolonged intermittent renal replacement therapy.
The aim of this study was to describe the population pharmacokinetics of vancomycin during prolonged intermittent renal replacement therapy (PIRRT) in critically ill patients with acute kidney injury. ⋯ This is the first population pharmacokinetic study of vancomycin in patients receiving PIRRT and we observed large pharmacokinetic variability. Empirically, weight-based doses that are appropriate for the duration of PIRRT, should be selected and supplemented with therapeutic drug monitoring.