Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
-
J. Physiol. Pharmacol. · Apr 2013
Adiponectin and leptin receptors expression in Barrett's esophagus and normal squamous epithelium in relation to central obesity status.
Esophageal adenocarcinoma incidence is rapidly increasing which may be due to the growing incidence of Barrett's esophagus (BE) and obesity. The mechanisms linking obesity and progression of Barrett's carcinogenesis is poorly understood. The aim of the study was to evaluate the expression of adipokines receptors in BE and in normal squamous epithelium in the same patients in correlation with obesity parameters. ⋯ in opposite to the prior hypothesis adiponectin and leptin receptors activation in BE may be not caused by obesity.
-
J. Physiol. Pharmacol. · Apr 2013
Modulation of metabolic and cardiac dysfunctions by swimming in overweight rats on a high cholesterol and fructose diet: possible role of adiponectin.
Western diet rich in cholesterol and sucrose with decreased physical activity cause overweight and metabolic syndrome. The aim of the present study was to investigate the effect of swimming on the cardiac adiponectin mRNA expression in high cholesterol and fructose fed rats. Forty Sprague-Dawley male rats divided into 2 equal groups. ⋯ Also, there was an over-expression of down-expressed cardiac adiponectin gene. Also, ventricular functions were ameliorated by swimming exercise training. Swimming exercise partially improved the ventricular function that could be possibly explained through increased the cardiac expression of adiponectin.