Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
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J. Physiol. Pharmacol. · Aug 2017
ReviewCrataegus special extract WS 1442: up-to-date review of experimental and clinical experiences.
Extracts and tinctures made from Crataegus spp. (Hawthorn) have been used as cardioprotective remedies since ancient times. WS 1442 special extract, manufactured by Dr. W. ⋯ Moreover, WS 1442 also carries proven vasorelaxant activity, via affecting eNOS synthase, and prevents ischemic heart tissue swelling by influence on calcium signaling pathways, and thus detain hyperpermeability of endothelium. Actions of WS 1442 special extract were investigated in in vitro as well as in vivo studies including large clinical trials. In this review authors present current state of knowledge about possible beneficial effects of WS 1442 special extract on cardiovascular system.
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J. Physiol. Pharmacol. · Aug 2017
Association between standard laboratory and functional tests of coagulation in dilutional coagulopathy: an in vitro study.
Standard laboratory tests (SLTs) of coagulation are in common use in clinical practice. We aimed to determine the association between SLTs and functional tests of coagulation in blood samples diluted with balanced crystalloid and colloid solutions in an ex vivo setting. The study group comprised 32 healthy young male volunteers. ⋯ Fibrinogen concentration correlated positively with fibrinogen function as determined by FIBTEM (i.e. fibrinogen deficiency/dysfunction screening test) maximum clot firmness (R = 0.49 to 0.73; P < 0.05). ROTEM results were predominantly associated with fibrinogen concentration and number of platelets. When there is no access to functional tests, concentration of fibrinogen is the most reliable test of coagulation, also in the context of fluid-induced coagulopathy.