Cardiology in the young
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Cardiology in the young · Apr 2011
Randomized Controlled Trial Comparative StudySildenafil therapy for neonatal and childhood pulmonary hypertensive vascular disease.
We hypothesised that sildenafil would improve hemodynamics in children with pulmonary hypertension and attenuate rebound pulmonary hypertension after inhaled nitric oxide withdrawal. ⋯ In children under 5 years of age with severe pulmonary hypertension, sildenafil therapy resulted in prolonged hemodynamic improvements without adverse effects. Sildenafil attenuated rebound pulmonary hypertension after withdrawal of inhaled nitric oxide.