Journal of back and musculoskeletal rehabilitation
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Myofascial pain syndrome (MPS) and fibromyalgia (FM) are common muscular pain syndromes. They are both characterized by tenderness, but MPS is further characterized by the myofascial trigger point that has a taut band and causes referred pain. FM can be either primary (idiopathic) or secondary. ⋯ Tryptophane is low in the serum and spinal fluid of FM patients, whereas substance P is elevated in the spinal fluid. Treatment of MPS is effective when the trigger point is inactivated and underlying mechanical or medical perpetuating factors are corrected. Treatment of fibromyalgia is more difficult as the drugs commonly used, such as the tricyclic antidepressants, which have uncertain benefits; and exercise, which clearly shows a short-term benefit, fail to provide long-lasting relief at 4 years.