The Annals of pharmacotherapy
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To examine the effects of adjunctive aripiprazole in patients with major depression refractory to adequate therapy with bupropion. ⋯ Adjunctive aripiprazole given in low doses resulted in rapid improvements in depressed patients who were refractory to adequate therapy with bupropion. Additional studies are required to determine whether these results can be generalized to other depressed individuals who are refractory to bupropion treatment.
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To evaluate the efficacy of gabapentin for the treatment of uremic pruritus (UP). ⋯ Available data support the use of gabapentin as a well-tolerated and effective treatment option for patients with UP who are unresponsive to traditional therapies. Further well-designed trials are warranted to establish the most appropriate dosing regimen in patients on HD.