The Annals of pharmacotherapy
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To report a case of increased aripiprazole concentrations during coadministration with darunavir, ritonavir, and duloxetine. ⋯ The interaction between aripiprazole and darunavir, ritonavir, and duloxetine may be significant. Clinicians should be cognizant of increased risk of aripiprazole toxicity in HIV-positive patients concurrently taking ritonavir-boosted ART and other cytochrome P450 inhibitors like duloxetine. Dose adjustments or monitoring parameters should be an area of research and discussion.