The Annals of pharmacotherapy
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To report a case of refractory nausea in a patient with idiopathic gastroparesis successfully treated with aprepitant. ⋯ Aprepitant may have some utility in treating refractory nausea caused by gastroparesis. This case suggests that the drug's antiemetic effect may be successfully used in areas not approved by the Food and Drug Administration. A controlled trial examining aprepitant in patients with such challenging clinical conditions may be warranted.