Journal of vascular and interventional radiology : JVIR
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The effect of pH neutralization on the pain experienced during intradermal lidocaine administration was investigated in a prospective blind study of 20 adult volunteers. A plain solution (pH congruent to 6.1) and three different buffered solutions of 1% lidocaine (pH values of 6.8, 7.0, and 7.2) were prepared, and a 0.5-mL intradermal injection of each was administered to the volar aspect of the forearm. ⋯ Solutions with a pH of less than 6.8 (unbuffered lidocaine in this study) predictably produced a burning pain sensation on injection. However, buffering of 1% lidocaine above a pH of 6.8 significantly (P less than .05) reduced the mean quantitative pain estimates compared with the nonbuffered controls.
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J Vasc Interv Radiol · Feb 1992
Case ReportsPaucity of angiographic findings despite extensive organized thrombus in chronic thromboembolic pulmonary hypertension.
The authors describe a patient with chronic thromboembolic pulmonary hypertension. At pulmonary angiography, only severe hypertension with pruning of peripheral vessels was seen; the right pulmonary artery appeared normal. ⋯ At autopsy, a laminated well-organized thrombus that occupied virtually all of the right pulmonary artery and adhered to the vessel wall was seen. Other modalities should be investigated to help establish the diagnosis of chronic thromboembolic pulmonary hypertension.