Journal of vascular and interventional radiology : JVIR
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J Vasc Interv Radiol · Aug 2011
A phase III, open-label, single-arm study of tenecteplase for restoration of function in dysfunctional central venous catheters.
To evaluate, in a phase III, single-arm study, the safety and efficacy of the thrombolytic agent tenecteplase in restoring function to dysfunctional central venous catheters (CVCs). ⋯ Consecutive administration of one or two doses of tenecteplase into CVCs showed efficacy in the restoration of catheter function in patients with dysfunctional CVCs.