Journal of vascular and interventional radiology : JVIR
-
J Vasc Interv Radiol · Aug 2001
Randomized Controlled Trial Multicenter Study Clinical TrialRecombinant tissue plasminogen activator (alteplase) for restoration of flow in occluded central venous access devices: a double-blind placebo-controlled trial--the Cardiovascular Thrombolytic to Open Occluded Lines (COOL) efficacy trial.
Central venous access devices (CVADs) are a mainstay of current medical therapy but often become occluded by thrombus. Tissue plasminogen activator (alteplase), at a dose of 2 mg per 2 mL, has been shown to be effective in restoring flow to catheters proven by radiographic contrast injection to be occluded by thrombus. The purpose of this double-blind placebo-controlled multicenter trial was to determine the efficacy of alteplase in occluded catheters without earlier contrast injections or radiographic examinations. ⋯ Infusion of alteplase appeared to be safe and effective in restoring flow to occluded catheters without need for pretreatment radiographic evaluation.
-
J Vasc Interv Radiol · Feb 2001
Randomized Controlled Trial Clinical TrialTreatment of malignant pleural effusions with tunneled long-term drainage catheters.
To assess the effectiveness of tunneled pleural catheters (TPCs) in the treatment of malignant pleural effusions (MPEs). ⋯ Regardless of whether pleurodesis is achieved, TPCs provide effective long-term outpatient palliation of MPEs.
-
J Vasc Interv Radiol · Sep 1996
Randomized Controlled Trial Comparative Study Clinical TrialPropofol versus midazolam for sedation during percutaneous transluminal angioplasty.
To prospectively and randomly compare use of propofol versus midazolam for sedation during percutaneous transluminal angioplasty (PTA). ⋯ Propofol causes less respiratory depression than midazolam for equivalent sedation and anxiolysis in patients undergoing PTA.
-
J Vasc Interv Radiol · Jan 1994
Randomized Controlled Trial Clinical TrialReducing the discomfort of lidocaine administration through pH buffering.
A prospective, double-blind study was undertaken to evaluate the effect of using a buffered lidocaine solution on the perception of pain experienced by a patient during its intradermal injection. ⋯ Buffering lidocaine significantly decreased the discomfort associated with its administration as a local anesthetic.
-
J Vasc Interv Radiol · Jul 1993
Randomized Controlled Trial Clinical TrialRandomized double-blind clinical trial of celiac plexus block for percutaneous biliary drainage.
This study was undertaken to determine the efficacy of celiac plexus block (CPB) as a method of providing analgesia for percutaneous biliary drainage (PBD). ⋯ This study indicates that CPB is not an effective means of providing additional visceral pain relief over and above that which can be accomplished with self-administered intravenous medication for patients who undergo PBD.