Internal medicine
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Randomized Controlled Trial
The effect of ethinylestradiol (EE)/cyproterone acetate (CA) and EE/CA plus metformin treatment on adhesion molecules in cases with polycystic ovary syndrome (PCOS).
To determine if EE/CA and EE/CA plus metformin treatment have any effect on adhesion molecules in cases with PCOS. ⋯ These results demonstrate that EE/CA+metformin treatment reduced inflammation markers in cases with PCOS compared to EE/CA treatment. The clinical relevance of this conclusion may be clarified by longer metformin treatment and clinical follow-up.