Internal medicine
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Meta Analysis
Meta-analysis of the ADH1B and ALDH2 polymorphisms and the risk of colorectal cancer in East Asians.
The aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) genes have been implicated in the development of colorectal cancer (CRC). However, the results are inconsistent. In this study, a meta-analysis was performed to assess the associations between the ALDH2 and ADH1B polymorphisms and the risk of CRC. ⋯ This meta-analysis demonstrated that the ALDH2 polymorphism, but not the ADH1B polymorphism, significantly increases the risk of CRC in East Asians.
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To evaluate the association between vitamin D receptor (VDR) BsmI gene polymorphism and the risk of end-stage renal disease (ESRD). ⋯ VDR BsmI gene polymorphism appears to not be associated with the risk of ESRD in the overall population, Caucasians or Asians. However, more studies should be performed in the future.