Lupus
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Case Reports
Water intoxication induced by low-dose cyclophosphamide in two patients with systemic lupus erythematosus.
Cyclophosphamide (CY) is an alkylating agent used to treat a variety of autoimmune disorders. Water intoxication is a well-known complication of high-dose intravenous (i.v.) CY, but is rare in patients treated with low dose i.v. CY. ⋯ This potentially life-threatening complication of i.v. CY could be minimized by avoidance of overhydration following pulse i.v. CY.