Journal of diabetes and its complications
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J. Diabetes Complicat. · Jul 2012
Randomized Controlled TrialThe effect of ubiquinone in diabetic polyneuropathy: a randomized double-blind placebo-controlled study.
Diabetic polyneuropathy aetiology is based on oxidative stress generation due to production of reactive oxygen species. Ubiquinone is reduced to ubiquinol and redistributed into lipoproteins, possibly to protect them from oxidation. ⋯ Twelve weeks treatment with ubiquinone improves clinical outcomes and nerve conduction parameters of diabetic polyneuropathy; furthermore, it reduces oxidative stress without significant adverse events.