American journal of clinical pathology
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Am. J. Clin. Pathol. · May 2015
CALR, JAK2, and MPL mutation profiles in patients with four different subtypes of myeloproliferative neoplasms: primary myelofibrosis, essential thrombocythemia, polycythemia vera, and myeloproliferative neoplasm, unclassifiable.
We investigated mutation profiles of CALR, JAK2, and MPL in 199 Korean patients with myeloproliferative neoplasms (MPNs). ⋯ The prognostic significance of CALR mutations likely differs among the MPN subtypes.
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Am. J. Clin. Pathol. · May 2015
Case ReportsParadoxical bleeding and thrombosis in a patient with afibrinogenemia and fibrinogen Mumbai mutation.
Thrombosis is rarely reported in cases of afibrinogenemia and is generally associated with thrombophilia or replacement therapy. Often, it is difficult to predict whether the patients will bleed or whether they are exposed to the risk of thrombosis. ⋯ Presence of both bleeding and thrombotic manifestations in a patient with afibrinogenemia in the presence of other associated risk factors warrants a very careful individualized approach in the management of patients with afibrinogenemia.